1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR
  3. c-Met-IN-17

c-Met-IN-17 is a potent c-Met kinase inhibitor with an IC50 of 0.031 μM. c-Met-IN-17 can be used in anticancer research.. c-Met-IN-17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

c-Met-IN-17 Chemical Structure

c-Met-IN-17 Chemical Structure

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Description

c-Met-IN-17 is a potent c-Met kinase inhibitor with an IC50 of 0.031 μM. c-Met-IN-17 can be used in anticancer research.[1]. c-Met-IN-17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

C-met-in-17 (compound 29) inhibits D1228V c-Met enzyme activity with an IC50 of 0.068 μM by ADP-Glo assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

c-Met-IN-17 (0.5 mg/kg; i.v.; 0-24 h) shows excellent bioavailability in Wistar Rats[1].
In vivo pharmacokinetic analysis in Wistar Rats[1]

Route Dose (mg/kg) Cl (mL/min/kg) Vss_obs (L/kg) Bioavailability (%)
i.v. 0.5 60 4.6 100

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

374.37

Formula

C21H15FN4O2

SMILES

FC1=CC2=C(C(C3=CN(C(NC3=O)=O)C(C4=CC=CC=C4)C)=C1)NN=C2C#C

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
c-Met-IN-17
Cat. No.:
HY-153831
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