c-Myc inhibitor 7 

c-Myc inhibitor 7 is a c-Myc inhibitor and a multiple target protein degrader (PROTAC). c-Myc inhibitor 7 effective degrades c-MYC, CK1α, GSPT1 and IKZF1/2/3 proteins in a variety of tumor cells. c-Myc inhibitor 7 can be used for c-Myc high expression related disease research, such as cancer, cardiovascular and cerebrovascular diseases, and viral infection (Pink: c-Myc ligand (HY-168685); Blue: E3 ligase ligand (HY-W093472); Black: linker (HY-W015808))^[1].

c-Myc inhibitor 7 (0-10 mM; 3 days) inhibits cell proliferation of HL60 cells with an IC₅₀ value of 0.5 nM^[1].
c-Myc inhibitor 7 promotes 60-90% cell protein degradation of HL60 cells^[1].
c-Myc inhibitor 7 (1, 3, 10 and 100 nM; 24 hours) degrades c-Myc, CKla, GSPTl, IKZFl , IKZF2 and IKZF3 proteins in multi-cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

614.65

C₃₅H₃₀N₆O₅

2883535-99-5

O=C(C1=CC=C2C(N(C3C(NC(CC3)=O)=O)CC2=C1)=O)NCC4=CC=C(CNC(CN5C6=C(C7=CC=CC=C75)C=CC=N6)=O)C=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. TONG YOUZHI, et al. 2,6-Dioxopiperidine compounds as c-Myc inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. WO2022268066. 2022.