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  5. C-Type Natriuretic Peptide (CNP) (1-22), human TFA

C-Type Natriuretic Peptide (CNP) (1-22), human TFA 

Cat. No.: HY-P1237A Purity: 98.10%
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C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor.

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C-Type Natriuretic Peptide (CNP) (1-22), human TFA Chemical Structure

C-Type Natriuretic Peptide (CNP) (1-22), human TFA Chemical Structure

CAS No. : 1966153-17-2

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Based on 1 publication(s) in Google Scholar

Other Forms of C-Type Natriuretic Peptide (CNP) (1-22), human TFA:

C-Type Natriuretic Peptide (CNP) (1-22), human TFA Related Antibodies

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Description

C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor[1][2][3].

IC50 & Target[1]

NPR-B

 

In Vitro

C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) (0.01, 0.1, 1, 10, 100, 1000 nM) increases cGMP production in CHO cells expressing human NPR-B in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C-Type Natriuretic Peptide (CNP) (1-22), human TFA Related Antibodies
In Vivo

PK parameters of CNP immunoreactivity after a single intravenous administration of C-Type Natriuretic Peptide (CNP) (1-22), human[1]:

Dose
(nM/kg)		 AUC0-∞
(pM·min/mL)		 MRT0-∞
(min)		 T1/2
(min)		 CLtot
(mL/min/kg)		 Vdss
(mL/kg)
20 320±54 1.02±0.18 1.42±0.45 63.9±11.9 64.2±5.1
PK parameters of CNP immunoreactivity after a single subcutaneous administration of C-Type Natriuretic Peptide (CNP) (1-22), human[1]:
Dose
(nM/kg)		 Cmax
(pM/mL)		 Tmax
(min)		 AUC0-∞
(pM·min/mL)		 MRT0-∞
(min)		 T1/2
(min)		 BA
(%)
50 9.02±3.74 5.0±0.0 152±73 13.9±3.4 10.0±5.0 19±9
Each value represents the mean±SD of 3 rats. MRT=mean residence time, CLtot=total clearance, T1/2=half-life period, BA=bioavailability.
C-Type Natriuretic Peptide (CNP) (1-22) ( i.c.v.) in a dose of 2 nM induces an increase in the severity of picrotoxin-kindled convulsions 24 and 48 hrs after application of the peptide[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

2311.62

Formula

C95H158F3N27O30S3
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

GLSKGCFGLKLDRIGSMSGLGC (Disulfide bridge: Cys6-Cys22)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 2 mg/mL (0.87 mM; Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References
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C-Type Natriuretic Peptide (CNP) (1-22), human TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C-Type Natriuretic Peptide (CNP) (1-22), human1966153-17-2OthersCNPcAMP synthesisheart transplantdeveloping kidneyhypertrophied kidneyseizure syndromeInhibitorinhibitorinhibit

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