2. Immunology/Inflammation
  3. Complement System
  4. C3a (70-77) (TFA)

C3a (70-77) (TFA)  (Synonyms: Complement 3a (70-77) (TFA))

Cat. No.: HY-P1505A Purity: 95.02%
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C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

C3a (70-77) (TFA) Chemical Structure

C3a (70-77) (TFA) Chemical Structure

Size Price Stock Quantity
1 mg USD 80 In-stock
5 mg USD 190 In-stock
10 mg USD 320 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of C3a (70-77) (TFA):

C3a (70-77) (TFA) Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE C3a (70-77) (TFA)

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

C3a (70-77) TFA (Complement 3a (70-77) TFA) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a[1][2].

In Vitro

The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD[1].
C3a (70-77) induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. The cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C3a (70-77) (TFA) Related Antibodies
Molecular Weight

937.96

Formula

C37H62F3N13O12
Appearance

Solid

Color

White to off-white

Sequence

Ala-Ser-His-Leu-Gly-Leu-Ala-Arg
Sequence Shortening

ASHLGLAR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (106.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0661 mL 5.3307 mL 10.6614 mL
5 mM 0.2132 mL 1.0661 mL 2.1323 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (106.61 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.0661 mL 5.3307 mL 10.6614 mL 26.6536 mL
5 mM 0.2132 mL 1.0661 mL 2.1323 mL 5.3307 mL
10 mM 0.1066 mL 0.5331 mL 1.0661 mL 2.6654 mL
15 mM 0.0711 mL 0.3554 mL 0.7108 mL 1.7769 mL
20 mM 0.0533 mL 0.2665 mL 0.5331 mL 1.3327 mL
25 mM 0.0426 mL 0.2132 mL 0.4265 mL 1.0661 mL
30 mM 0.0355 mL 0.1777 mL 0.3554 mL 0.8885 mL
40 mM 0.0267 mL 0.1333 mL 0.2665 mL 0.6663 mL
50 mM 0.0213 mL 0.1066 mL 0.2132 mL 0.5331 mL
60 mM 0.0178 mL 0.0888 mL 0.1777 mL 0.4442 mL
80 mM 0.0133 mL 0.0666 mL 0.1333 mL 0.3332 mL
100 mM 0.0107 mL 0.0533 mL 0.1066 mL 0.2665 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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C3a (70-77) (TFA) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C3a (70-77) (TFA)Complement 3a (70-77) (TFA)Complement SystemInhibitorinhibitorinhibit

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