2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. CAA-0225

CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites[1][2][3].

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CAA-0225 Chemical Structure

CAA-0225 Chemical Structure

CAS No. : 244072-26-2

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CAA-0225 Related Antibodies

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Description

CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites[1][2][3].
IC50 & Target

cathepsin L

 

In Vitro

CAA-0225 (10 mg/mL, 4 h) acts as a probe for autophagic protein hydrolysis by specifically inhibiting the involvement of protease L in the degradation of autophagosome membrane markers LC3-II and GABARAP[1].
CAA-0225 (0-100 μM, 48 h) kills Trypanosoma brucei parasite by inhibiting tissue protease L[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAA-0225 Related Antibodies

Western Blot Analysis[1].

Cell Line: HeLa、Huh-7 cells
Concentration: 10 mg/mL
Incubation Time: 4 h
Result: Inhibited the degradation of microtubule associated protein IA/IB light chain 3-II (LC3-II) and gamma aminobutyric acid (A) receptor associated protein (GABARAP)-II

Cell Proliferation Assay[3].

Cell Line: Bloodstream forms of T. brucei clone 427–221a
Concentration: 0-100 μM
Incubation Time: 48 h
Result: Inhibited the growth of trypanosomes in a dose-dependent manner with GI50 values of 0.33 μM, respectively
In Vivo

CAA-0225 (0.25 mg, i.v.) improves cardiac function and reduces infarct size by inhibiting the release of cardiac cathepsin L in a mouse model of reperfusion after myocardial infarction[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Model of reperfusion injury involved male C57Bl/6 mice aged 9–12 weeks[2].
Dosage: 0.25 mg
Administration: Intravenous injection (i.v.)
Result: Reduced infarct size, improved systolic and diastolic cardiac function.
Molecular Weight

487.55

Formula

C28H29N3O5
CAS No.
SMILES

O=C([C@H]1O[C@@H]1C(N[C@@H](CC2=CC=CC=C2)C(NCC3=CC=CC=C3)=O)=O)NCCC4=CC=C(O)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CAA-0225 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAA-0225244072-26-2CAA0225CAA 0225Cathepsinautophagycardiac functionHeLa cellHuh-7 celltrypanosoma bruceiInhibitorinhibitorinhibit

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