Calcium Channel antagonist 3

Cat. No.: HY-156664 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Calcium Channel antagonist 3 (compound 397) is an inhibitor of voltage-gated calcium channels with an IC₅₀ value of 5-20μM.

For research use only. We do not sell to patients.

Calcium Channel antagonist 3 Chemical Structure

CAS No. : 687573-14-4

Size	Price	Stock	Quantity
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
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100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
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Description

Calcium Channel antagonist 3 (compound 397) is an inhibitor of voltage-gated calcium channels with an IC₅₀ value of 5-20μM^[1].

Molecular Weight

426.53

Formula

C₂₃H₂₆N₂O₄S

CAS No.

687573-14-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C)C2=C(C=CC(S(=O)(N3CCCC(C3)C)=O)=C2)O1)NCC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (117.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3445 mL	11.7225 mL	23.4450 mL
5 mM	0.4689 mL	2.3445 mL	4.6890 mL
10 mM	0.2345 mL	1.1723 mL	2.3445 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

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Data Sheet (268 KB) SDS (251 KB)

COA (249 KB) HNMR (138 KB)

Handling Instructions (2659 KB)

References

[1]. Termin, Andreas P, et, al. Benzofuran, indole and benzothiophene sulfonamide calcium channel antagonists for treating pain. WO2006010008 A1 2006-01-26.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3445 mL	11.7225 mL	23.4450 mL	58.6125 mL
	5 mM	0.4689 mL	2.3445 mL	4.6890 mL	11.7225 mL
	10 mM	0.2345 mL	1.1723 mL	2.3445 mL	5.8613 mL
	15 mM	0.1563 mL	0.7815 mL	1.5630 mL	3.9075 mL
	20 mM	0.1172 mL	0.5861 mL	1.1723 mL	2.9306 mL
	25 mM	0.0938 mL	0.4689 mL	0.9378 mL	2.3445 mL
	30 mM	0.0782 mL	0.3908 mL	0.7815 mL	1.9538 mL
	40 mM	0.0586 mL	0.2931 mL	0.5861 mL	1.4653 mL
	50 mM	0.0469 mL	0.2345 mL	0.4689 mL	1.1723 mL
	60 mM	0.0391 mL	0.1954 mL	0.3908 mL	0.9769 mL
	80 mM	0.0293 mL	0.1465 mL	0.2931 mL	0.7327 mL
	100 mM	0.0234 mL	0.1172 mL	0.2345 mL	0.5861 mL