2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Proton Pump Calcium Channel
  4. Caloxin 1C2

Caloxin 1C2 is a specific PMCA (plasma-membrane Ca2+-ATPases) inhibitor. Caloxin 1C2 is selective for PMCA4 over PMCA1, 2 and 3. The Ki values of Caloxin 1C2 are 2.3 μM for PMCA4 and 21 μM for PMCA1. Caloxin 1C2 dose not cause any significant effects on total Ca2+ transfer. Caloxin 1C2 affects coronary contractility.

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Caloxin 1C2 Chemical Structure

Caloxin 1C2 Chemical Structure

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Caloxin 1C2 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

Caloxin 1C2 is a specific PMCA (plasma-membrane Ca2+-ATPases) inhibitor. Caloxin 1C2 is selective for PMCA4 over PMCA1, 2 and 3. The Ki values of Caloxin 1C2 are 2.3 μM for PMCA4 and 21 μM for PMCA1. Caloxin 1C2 dose not cause any significant effects on total Ca2+ transfer. Caloxin 1C2 affects coronary contractility[1][2].

IC50 & Target

Ki: 2.3±0.3 μM (PMCA4), 21±6 μM (PMCA1)[2]
Molecular Weight

1844.08

Formula

C80H134N26O24
Appearance

Solid

Color

White to off-white

Sequence

Thr-Ala-Trp-Ser-Glu-Val-Leu-Asp-Leu-Leu-Arg-Arg-Gly-Gly-Gly-Ser-Lys-NH2
Sequence Shortening

TAWSEVLDLLRRGGGSK-NH2
SMILES

O=C(N[C@@H](C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (54.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5423 mL 2.7114 mL 5.4228 mL
5 mM 0.1085 mL 0.5423 mL 1.0846 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5423 mL 2.7114 mL 5.4228 mL 13.5569 mL
5 mM 0.1085 mL 0.5423 mL 1.0846 mL 2.7114 mL
10 mM 0.0542 mL 0.2711 mL 0.5423 mL 1.3557 mL
15 mM 0.0362 mL 0.1808 mL 0.3615 mL 0.9038 mL
20 mM 0.0271 mL 0.1356 mL 0.2711 mL 0.6778 mL
25 mM 0.0217 mL 0.1085 mL 0.2169 mL 0.5423 mL
30 mM 0.0181 mL 0.0904 mL 0.1808 mL 0.4519 mL
40 mM 0.0136 mL 0.0678 mL 0.1356 mL 0.3389 mL
50 mM 0.0108 mL 0.0542 mL 0.1085 mL 0.2711 mL
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Caloxin 1C2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Caloxin 1C2Proton PumpCalcium ChannelCa2+ channelsCa channelsPMCAplasma-membrane Ca2+-ATPasescoronary contractilityInhibitorinhibitorinhibit

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