Caloxin 1C2 

Caloxin 1C2 is a specific PMCA (plasma-membrane Ca²⁺-ATPases) inhibitor. Caloxin 1C2 is selective for PMCA4 over PMCA1, 2 and 3. The K_i values of Caloxin 1C2 are 2.3 μM for PMCA4 and 21 μM for PMCA1. Caloxin 1C2 dose not cause any significant effects on total Ca²⁺ transfer. Caloxin 1C2 affects coronary contractility^[1][2].

Ki: 2.3±0.3 μM (PMCA4), 21±6 μM (PMCA1)^[2]

1844.08

C₈₀H₁₃₄N₂₆O₂₄

Thr-Ala-Trp-Ser-Glu-Val-Leu-Asp-Leu-Leu-Arg-Arg-Gly-Gly-Gly-Ser-Lys-NH2

TAWSEVLDLLRRGGGSK-NH2

O=C(N[C@@H](C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)N

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sillanpää JK, et al. Calcium transfer across the outer mantle epithelium in the Pacific oyster, Crassostrea gigas. Proc Biol Sci. 2018 Nov 14;285(1891):20181676.  [Content Brief]

  [2]. Pande J, et al. Functional effects of caloxin 1c2, a novel engineered selective inhibitor of plasma membrane Ca(2+)-pump isoform 4, on coronary artery. J Cell Mol Med. 2008 Jun;12(3):1049-60.  [Content Brief]