2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Calpain Inhibitor-2

Calpain Inhibitor-2 (compound 5) is a peptide inhibitor of μ-calpain (Ki=9 nM). Calpain Inhibitor-2 exhibits antiproliferative activity against melanoma cell lines (A-375 and B-16F1) and PC-3 prostate cancer cells in vitro.

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Calpain Inhibitor-2 Chemical Structure

Calpain Inhibitor-2 Chemical Structure

CAS No. : 2413962-65-7

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Calpain Inhibitor-2 Related Antibodies

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Description

Calpain Inhibitor-2 (compound 5) is a peptide inhibitor of μ-calpain (Ki=9 nM). Calpain Inhibitor-2 exhibits antiproliferative activity against melanoma cell lines (A-375 and B-16F1) and PC-3 prostate cancer cells in vitro[1].

Cellular Effect
Cell Line Type Value Description References
A-375 GI50
16 μM
Compound: 5
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
[PMID: 32199690]
B16-F1 GI50
17.2 μM
Compound: 5
Antiproliferative activity against mouse B16-F1 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
Antiproliferative activity against mouse B16-F1 cells assessed as inhibition of cell growth after 48 hrs by sulforhodamine B colorimetric assay
[PMID: 32199690]
PC-3 GI50
6.02 μM
Compound: 5
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth after 72 hrs by MTT assay
[PMID: 32199690]
Molecular Weight

499.62

Formula

C26H33N3O5S
CAS No.
SMILES

CC(C[C@@H](C(C(N)=O)=O)NC([C@H](C(C)C)NS(=O)(C1=CC=C(C=C1)/C=C/C2=CC=CC=C2)=O)=O)C
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Purity & Documentation
References
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Calpain Inhibitor-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Calpain Inhibitor-22413962-65-7Calpain Inhibitor2Calpain Inhibitor 2Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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