2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. Cannabisin F

Cannabisin F is a SIRT1 modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2.

For research use only. We do not sell to patients.

Cannabisin F Chemical Structure

Cannabisin F Chemical Structure

CAS No. : 163136-19-4

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Based on 1 publication(s) in Google Scholar

Cannabisin F Related Antibodies

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Description

Cannabisin F is a SIRT1 modulator. Cannabisin F, as a hempseed lignanamide, can be used for the research of anti-inflammatory and anti-oxidative. Cannabisin F may be a potential agent of neurodegenerative diseases as modulators of SIRT1/NF-κB and Nrf2[1].

IC50 & Target

SIRT1[1]
In Vitro

Cannabisin F (0~15 μM; 1 hour; BV2 microglia cells) inhibits the phosphorylation of IκBα, p65, but enhances the expression of Nrf2 and HO-1[1].
Cannabisin F (0~15 μM; 24 hours; BV2 microglia cells) has no significant effect on cell survival, inhibits IL-6 and TNF-α production and their mRNA expression, inhibits the production of ROS and increases the expression of SIRT1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cannabisin F Related Antibodies

Cell Viability Assay[1]

Cell Line: BV2 microglia cells
Concentration: 0~15 µM
Incubation Time: 24 hours
Result: Had no significant effect on cell survival.

Western Blot Analysis[1]

Cell Line: BV2 microglia cells
Concentration: 0~15 µM
Incubation Time: 1 hour
Result: Inhibited the phosphorylation of IκBα, p65, but enhanced the expression of Nrf2 and HO-1.
Molecular Weight

624.68

Formula

C36H36N2O8
CAS No.
SMILES

COC1=C(O)C=CC(/C=C(C(NCCC2=CC=C(O)C=C2)=O)\OC3=C(C=C(/C=C/C(NCCC4=CC=C(O)C=C4)=O)C=C3)OC)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Cannabisin F Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cannabisin F163136-19-4Sirtuinhempseedlignanamideanti-inflammatoryanti-oxidativepotentialneurodegenerativeInhibitorinhibitorinhibit

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