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  6. CAQK peptide

CAQK peptide selectively binds to injured mouse brain. CAQK peptide selectively targets demyelinating areas and it is absent from healthy tissue. The CAQK peptide target is a proteoglycan complex upregulated in brain injuries and is used for drug delivery. CAQK peptide can penetrate the blood-brain barrier.

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CAQK peptide Chemical Structure

CAQK peptide Chemical Structure

CAS No. : 2088281-24-5

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10 mg USD 110 In-stock
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Based on 1 publication(s) in Google Scholar

CAQK peptide Related Antibodies

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Description

CAQK peptide selectively binds to injured mouse brain. CAQK peptide selectively targets demyelinating areas and it is absent from healthy tissue. The CAQK peptide target is a proteoglycan complex upregulated in brain injuries and is used for drug delivery. CAQK peptide can penetrate the blood-brain barrier[1][2].

In Vitro

FAM-CAQK selectively associates with focal and impact-induced brain lesions while not interacting with healthy brain and other tissues. At lesion sites, the peptide is primarily associated with the fibrous extracellular matrix (ECM) deposited in interstitial spaces proximal to reactive astrocytes[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAQK peptide Related Antibodies
In Vivo

CAQK (100 nmoles/100 μL into the tail vein; at 24 h or 5 days post-injury) homes to lysolecithin-induced focal lesions in the spinal cord.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J 8-week-old male mice[1]
Dosage: 100 nmoles/100 μl in PBS
Administration: Tail vein; at 24 h or 5 days post-injury (focal demyelination was induced by stereotaxic injection of 1 μL of 1% lysolecithin solution into the right ventral)
Result: Caused the accumulation of peptide at the injury site by an increased density of mononucleated DAPI+ cells and fragmented myelin stained for myelin basic protein.
The peptide was not detected in the spinal cords of control sham-operated (PBS injected) mice showing regular densities of DAPI+ cells.
Molecular Weight

448.54

Formula

C17H32N6O6S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cys-Ala-Glu-Lys
Sequence Shortening

CAQK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (222.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2295 mL 11.1473 mL 22.2946 mL
5 mM 0.4459 mL 2.2295 mL 4.4589 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2295 mL 11.1473 mL 22.2946 mL 55.7364 mL
5 mM 0.4459 mL 2.2295 mL 4.4589 mL 11.1473 mL
10 mM 0.2229 mL 1.1147 mL 2.2295 mL 5.5736 mL
15 mM 0.1486 mL 0.7432 mL 1.4863 mL 3.7158 mL
20 mM 0.1115 mL 0.5574 mL 1.1147 mL 2.7868 mL
25 mM 0.0892 mL 0.4459 mL 0.8918 mL 2.2295 mL
30 mM 0.0743 mL 0.3716 mL 0.7432 mL 1.8579 mL
40 mM 0.0557 mL 0.2787 mL 0.5574 mL 1.3934 mL
50 mM 0.0446 mL 0.2229 mL 0.4459 mL 1.1147 mL
60 mM 0.0372 mL 0.1858 mL 0.3716 mL 0.9289 mL
80 mM 0.0279 mL 0.1393 mL 0.2787 mL 0.6967 mL
100 mM 0.0223 mL 0.1115 mL 0.2229 mL 0.5574 mL
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CAQK peptide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAQK peptide2088281-24-5Othersdrug deliverydemyelinating areasproteoglycan complexblood-brain barrierInhibitorinhibitorinhibit

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