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  3. Carbamoyl phosphate dilithium salt

Carbamoyl phosphate dilithium salt is an antisickling agent and plays a significant role in the urea cycle. Carbamoyl phosphate dilithium salt carbamylates the amino-terminal valine residues of hemoglobin S in erythrocytes, which interferes with the sickling phenomenon. Carbamoyl phosphate dilithium salt exhibits toxicity due to the lithium cation.

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Carbamoyl phosphate dilithium salt Chemical Structure

Carbamoyl phosphate dilithium salt Chemical Structure

CAS No. : 1866-68-8

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Description

Carbamoyl phosphate dilithium salt is an antisickling agent and plays a significant role in the urea cycle. Carbamoyl phosphate dilithium salt carbamylates the amino-terminal valine residues of hemoglobin S in erythrocytes, which interferes with the sickling phenomenon. Carbamoyl phosphate dilithium salt exhibits toxicity due to the lithium cation[1].

Molecular Weight

152.89

Formula

CH2Li2NO5P

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N)OP(O[Li])(O[Li])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 20 mg/mL (130.81 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.5407 mL 32.7033 mL 65.4065 mL
5 mM 1.3081 mL 6.5406 mL 13.0813 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.5407 mL 32.7033 mL 65.4065 mL 163.5163 mL
5 mM 1.3081 mL 6.5407 mL 13.0813 mL 32.7033 mL
10 mM 0.6541 mL 3.2703 mL 6.5407 mL 16.3516 mL
15 mM 0.4360 mL 2.1802 mL 4.3604 mL 10.9011 mL
20 mM 0.3270 mL 1.6352 mL 3.2703 mL 8.1758 mL
25 mM 0.2616 mL 1.3081 mL 2.6163 mL 6.5407 mL
30 mM 0.2180 mL 1.0901 mL 2.1802 mL 5.4505 mL
40 mM 0.1635 mL 0.8176 mL 1.6352 mL 4.0879 mL
50 mM 0.1308 mL 0.6541 mL 1.3081 mL 3.2703 mL
60 mM 0.1090 mL 0.5451 mL 1.0901 mL 2.7253 mL
80 mM 0.0818 mL 0.4088 mL 0.8176 mL 2.0440 mL
100 mM 0.0654 mL 0.3270 mL 0.6541 mL 1.6352 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Carbamoyl phosphate dilithium salt
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