Carbonic anhydrase inhibitor 12 

Carbonic anhydrase inhibitor 12 is a potent CA II inhibitor, also has inhibitory activity in CA I (K_is of 1.72 and 271 nM in CA II and CA I, respectively). Carbonic anhydrase inhibitor 12 has potent anticancer activity against different cancer cell lines^[1].

Carbonic anhydrase inhibitor 12 (Compound 14h) (10 μM; 48 hours; single) has great influence on the specificity and the inhibitory potency against the different cancer cell lines^[1].
Carbonic anhydrase inhibitor 12 (2.4 μM in MCF-7 and 2.5 μM MDA-MB-231; 48 hours) can arrest the cell cycle of MCF-7 and MDA-MB-231 cells at the G2/M phase^[1].
Carbonic anhydrase inhibitor 12 (2.4 μM in MCF-7 and 2.5 μM MDA-MB-231; 48 hours) demonstrates an increase in the early apoptotic and late apoptotic phase in comparison to the control untreated cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

640.53

C₂₇H₂₂BrN₅O₅S₂

2883451-38-3

COC1=CC=C(C(C2=NC(SCC(C3=CC=C(C=C3)Br)=O)=NC(NC4=CC=C(C=C4)S(N)(=O)=O)=C2C#N)=C1)OC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Abdel-Mohsen HT, et al. Application of the dual-tail approach for the design and synthesis of novel Thiopyrimidine-Benzenesulfonamide hybrids as selective carbonic anhydrase inhibitors. Eur J Med Chem. 2022;228:114004.  [Content Brief]