2. Metabolic Enzyme/Protease
  3. 11β-HSD
  4. 1009583-83-8

1009583-83-8

(R)-BMS-816336 Chemical Structure

1009583-83-8

Chemical Structure

  • (R)-BMS-816336
  • CAS No: 1009583-83-8
    Formula: C21H27NO3
    Molecular Weight: 341.44
  • IUPAC Name: 2-((1R,2R,3S,5R,6R,7S)-6-hydroxy-2-phenyladamantan-2-yl)-1-(3-hydroxyazetidin-1-yl)ethan-1-one
  • InChIKey: OAAZMUGLOXGVNH-SCTVKTQDSA-N
  • SMILES: O[C@H]1[C@H]2C[C@@H]3[C@@](C4=CC=CC=C4)(CC(N5CC(O)C5)=O)[C@@H](C[C@H]1C3)C2

Biological Activity: (R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC50s of 14.5 nM, 50.3 nM and 16 nM, respectively [1].

Cat. No. Product Name Purity Description
HY-101930B (R)-BMS-816336 (R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC50s of 14.5 nM, 50.3 nM and 16 nM, respectively .

References

[1]. Ye XY, et al. Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60(12):4932-4948. [Content Brief]

Keywords:

(R)-BMS-816336