2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. 402955-58-2

402955-58-2

PF-03049423 Chemical Structure

402955-58-2

Chemical Structure

  • PF-03049423
  • CAS No: 402955-58-2
    Formula: C24H32N6O4.xHCl
  • SMILES: O=C1C(N2CCN(CC2)CCO)=NC3=C(N1CCOCCC)C=C(C4=CC=C(OC)N=C4)N=C3.[x HCl]

Biological Activity: PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke[1].

Cat. No. Product Name Purity Description
HY-10679A PF-03049423 PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke.

References

[1]. Menniti FS, et al. Phosphodiesterase 5A inhibitors improve functional recovery after stroke in rats: optimized dosing regimen with implications for mechanism. J Pharmacol Exp Ther. 2009 Dec;331(3):842-50. [Content Brief]

Keywords:

PF-03049423