2. PI3K/Akt/mTOR
  3. PI3K mTOR
  4. 2742732-92-7

2742732-92-7

YX968 Chemical Structure

2742732-92-7

Chemical Structure

  • YX968
  • CAS No: 2742732-92-7
    Formula: C45H66N8O5S
    Molecular Weight: 831.12
  • InChIKey: KBTKRNXLECYGBY-NERSTHRASA-N
  • SMILES: CCCNNC(C(C=C1)=CC=C1N(CC2)CCN2CCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C5=C(N=CS5)C)C=C4)C)=O)=O)=O)=O

Biological Activity: YX968 is a potent and selective HDAC3/8 PROTAC dual degrader with DC50 values of 1.7 and 6.8 nM. YX968 exhibits antitumor activity by promoting apoptosis[1].(Pink: Target protein ligand (HY-168287); Black: linker (HY-W007700); Blue: E3 ligase ligand (HY-112078))

Cat. No. Product Name Purity Description
HY-164233 YX968 98.06% YX968 is a potent and selective HDAC3/8 PROTAC dual degrader with DC50 values of 1.7 and 6.8 nM. YX968 exhibits antitumor activity by promoting apoptosis.(Pink: Target protein ligand (HY-168287); Black: linker (HY-W007700); Blue: E3 ligase ligand (HY-112078))

References

[1]. Xiao Y, et al. HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation. Cell Chem Biol. 2023 Nov 16;30(11):1421-1435.e12. [Content Brief]

Keywords:

YX968