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2416223-41-9

IRE1α kinase-IN-3 Chemical Structure

2416223-41-9

Chemical Structure

  • IRE1α kinase-IN-3
  • CAS No: 2416223-41-9
    Formula: C29H32N6O3S
    Molecular Weight: 544.67
  • IUPAC Name: N-(5-((3-(2-(((1r,4r)-4-aminocyclohexyl)amino)pyrimidin-4-yl)pyridin-2-yl)oxy)naphthalen-1-yl)cyclobutanesulfonamide
  • InChIKey: QUZIUZXSSZJHTQ-MXVIHJGJSA-N
  • SMILES: O=S(NC1=CC=CC2=C1C=CC=C2OC3=C(C4=NC(N[C@H]5CC[C@@H](CC5)N)=NC=C4)C=CC=N3)(C6CCC6)=O

Biological Activity: IRE1α kinase-IN-3 (compound 2) is a potent IRE1α inhibitor with an Ki of 480 nM. IRE1α kinase-IN-3 is the ATP-competitive ligands of IRE1α[1].

Cat. No. Product Name Purity Description
HY-145418 IRE1α kinase-IN-3 IRE1α kinase-IN-3 (compound 2) is a potent IRE1α inhibitor with an Ki of 480 nM. IRE1α kinase-IN-3 is the ATP-competitive ligands of IRE1α.

References

[1]. Feldman HC, et al. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021 Nov;17(11):1148-1156. [Content Brief]

Keywords:

IRE1α kinase-IN-3