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2452019-67-7

FLT3/CDKs ligand-1 Chemical Structure

2452019-67-7

Chemical Structure

  • FLT3/CDKs ligand-1
  • CAS No: 2452019-67-7
    Formula: C26H31N9O3
    Molecular Weight: 517.58
  • InChIKey: NTWVVDYWEBCPNA-UHFFFAOYSA-N
  • SMILES: O=C(C1=NNC=C1NC2=C3C(NC=C3)=NC=N2)NC4=CC=C(CN5CCN(C(OC(C)(C)C)=O)CC5)C=C4

Biological Activity: FLT3/CDKs ligand-1 (Compound 14) is a ligand for target protein, which promotes the degradation of cyclin-dependent kinase (CDK) and the FMS-like tyrosine kinase 3 (FLT3), inhibits FLT3/CDK related proliferations and survivals of leukemia cells. LT3/CDKs ligand-1 can be used for synthesis of PROTAC FLT3/CDKs degrader-1 (HY-161708)[1].

Cat. No. Product Name Purity Description
HY-161709 FLT3/CDKs ligand-1 FLT3/CDKs ligand-1 (Compound 14) is a ligand for target protein, which promotes the degradation of cyclin-dependent kinase (CDK) and the FMS-like tyrosine kinase 3 (FLT3), inhibits FLT3/CDK related proliferations and survivals of leukemia cells. LT3/CDKs ligand-1 can be used for synthesis of PROTAC FLT3/CDKs degrader-1 (HY-161708).

References

[1]. Barik S. Expression and biochemical properties of a protein serine/threonine phosphatase encoded by bacteriophage lambda. Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10633-7. [Content Brief]

Keywords:

FLT3/CDKs ligand-1