2. Natural Products
  3. Disease Research Fields Plants Terpenoids
  4. Other Diseases Compositae Diterpenoids
  5. Trifolium hybridum L.
  6. 878670-61-2

878670-61-2

RDEA 806 Chemical Structure

878670-61-2

Chemical Structure

  • RDEA 806
  • CAS No: 878670-61-2
    Formula: C24H18BrClN4O3S
    Molecular Weight: 557.85
  • IUPAC Name: 4-(2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetamido)-3-chlorobenzoic acid
  • InChIKey: MPNGLQDRSJNLPL-UHFFFAOYSA-N
  • SMILES: ClC(C=C(C(O)=O)C=C1)=C1NC(CSC2=NN=C(Br)N2C3=CC=C(C4CC4)C5=C3C=CC=C5)=O

Biological Activity: RDEA 806 is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits potent in vitro inhibitory activity against both wild-type HIV-1 (EC50 = 3.05 nM) and NNRTI-resistant HIV-1[1].

Cat. No. Product Name Purity Description
HY-105249 RDEA 806 RDEA 806 is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) that exhibits potent in vitro inhibitory activity against both wild-type HIV-1 (EC50 = 3.05 nM) and NNRTI-resistant HIV-1.

References

[1]. Moyle G, et al. Phase 2a randomized controlled trial of short-term activity, safety, and pharmacokinetics of a novel nonnucleoside reverse transcriptase inhibitor, RDEA806, in HIV-1-positive, antiretroviral-naive subjects[J]. Antimicrobial agents and chemotherapy, 2010, 54(8): 3170-3178.

Keywords:

RDEA 806