2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. 1082954-71-9

1082954-71-9

A-987306 Chemical Structure

1082954-71-9

Chemical Structure

  • A-987306
  • CAS No: 1082954-71-9
    Formula: C18H25N5O
    Molecular Weight: 327.42
  • IUPAC Name: (7aS,11aS)-4-(piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine
  • InChIKey: DJKJVWJQAVGLHJ-YPMHNXCESA-N
  • SMILES: NC1=NC(N2CCNCC2)=C3CCC(O[C@]4([H])[C@@]5([H])CCCC4)=C5C3=N1

Biological Activity: A-987306 is a potent and oral bioavailable histamine H4 antagonist, with Kis of 3.4 nM and 5.8 nM for rat H4, and human H4. A-987306 shows anti-inflammatory activity in mice peritonitis model[1].

Cat. No. Product Name Purity Description
HY-14364 A-987306 A-987306 is a potent and oral bioavailable histamine H4 antagonist, with Kis of 3.4 nM and 5.8 nM for rat H4, and human H4. A-987306 shows anti-inflammatory activity in mice peritonitis model.

References

[1]. cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), A New Histamine H4R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia J. Med. Chem., 2008, 51 (22), pp 7094-7098

Keywords:

A-987306