2. Immunology/Inflammation
  3. Interleukin Related
  4. 2941091-91-2

2941091-91-2

BCL-xL/BCL-2 ligand 1 Chemical Structure

2941091-91-2

Chemical Structure

  • BCL-xL/BCL-2 ligand 1
  • CAS No: 2941091-91-2
    Formula: C48H53ClF3N5O7S3
    Molecular Weight: 1000.61
  • InChIKey: HDVWCEOOAUDYOR-GXQDVSBFSA-N
  • SMILES: O=C[C@@](C)(C1)CCC(C2=CC=C(C=C2)Cl)=C1CN3CCN(C4=CC=C(C=C4)C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(C=C5)N[C@@H](CSC6=CC=CC=C6)CCN7[C@]8([H])C[C@](OC8)([H])C7)=O)=O)CC3

Biological Activity: BCL-xL/BCL-2 ligand 1 (compound 72-1) is a BCL-xL and BCL-2 protein ligand. BCL-xL/BCL-2 ligand 1 can be connected to the E3 ligase by a linker to form PROTACs (HY-161410)[1][2].

Cat. No. Product Name Purity Description
HY-161415 BCL-xL/BCL-2 ligand 1 BCL-xL/BCL-2 ligand 1 (compound 72-1) is a BCL-xL and BCL-2 protein ligand. BCL-xL/BCL-2 ligand 1 can be connected to the E3 ligase by a linker to form PROTACs (HY-161410).

References

[1]. Guangrong Zheng, et al. Bcl-xl/bcl-2 dual degraders for treatment of cancers. WO2023107606A1.
[2]. Nayak D, et al. Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun. 2024 Mar 29;15(1):2743. [Content Brief]

Keywords:

BCL-xL/BCL-2 ligand 1