2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. 1093135-60-4

1093135-60-4

CPG-52364 Chemical Structure

1093135-60-4

Chemical Structure

  • CPG-52364
  • CAS No: 1093135-60-4
    Formula: C27H36N6O3
    Molecular Weight: 492.61
  • IUPAC Name: 6,7-dimethoxy-2-(4-(4-methylpiperazin-1-yl)phenyl)-N-(2-morpholinoethyl)quinazolin-4-amine
  • InChIKey: TUOZJWZCVIRDKO-UHFFFAOYSA-N
  • SMILES: CN1CCN(C2=CC=C(C3=NC(NCCN4CCOCC4)=C5C=C(OC)C(OC)=CC5=N3)C=C2)CC1

Biological Activity: CPG-52364 (compound 2) is a TLR9 antagonist. CPG-52364 inhibits the HEK293-hTLR9 cell with an IC50 value of 4.6 nM[1].

Cat. No. Product Name Purity Description
HY-120538 CPG-52364 98.49% CPG-52364 (compound 2) is a TLR9 antagonist. CPG-52364 inhibits the HEK293-hTLR9 cell with an IC50 value of 4.6 nM.

References

[1]. Manabu Watanabe, et al. Dihydropyrrolo[2,3-d]pyrimidines: Selective Toll-Like Receptor 9 Antagonists from Scaffold Morphing Efforts. ACS Med Chem Lett. 2014, 5, 11. [Content Brief]

Keywords:

CPG-52364