2. Immunology/Inflammation
  3. Tim3
  4. 1113126-49-0

1113126-49-0

TIM-3-IN-2 Chemical Structure

1113126-49-0

Chemical Structure

  • TIM-3-IN-2
  • CAS No: 1113126-49-0
    Formula: C25H23N3O6
    Molecular Weight: 461.47
  • InChIKey: CHBOMMCWIAPXIS-UHFFFAOYSA-N
  • SMILES: O=C(NC1=C(C=C(C=C1)OC)OC)COC2=CC=CC(C3=NC(C4=CC=C(C=C4)OC)=NO3)=C2

Biological Activity: TIM-3-IN-2 (Compound A-41) is a Tim3 inhibitor (KD: 0.61 μM). TIM-3-IN-2 blocks TIM-3 interactions with PtdSer, CEACAM1, and Gal-9. TIM-3-IN-2 inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 reverses the TIM-3-mediated blockade of the production of proinflammatory cytokines, and maximizes the T-cell antitumor activity against AML cell lines[1].

Cat. No. Product Name Purity Description
HY-155175 TIM-3-IN-2 99.36% TIM-3-IN-2 (Compound A-41) is a Tim3 inhibitor (KD: 0.61 μM). TIM-3-IN-2 blocks TIM-3 interactions with PtdSer, CEACAM1, and Gal-9. TIM-3-IN-2 inhibits the immunosuppressive function of TIM-3. TIM-3-IN-2 reverses the TIM-3-mediated blockade of the production of proinflammatory cytokines, and maximizes the T-cell antitumor activity against AML cell lines.

References

[1]. Abdel-Rahman SA, et al. Discovery of Small-Molecule TIM-3 Inhibitors for Acute Myeloid Leukemia Using Pharmacophore-Based Virtual Screening. J Med Chem. 2023 Aug 24;66(16):11464-11475. [Content Brief]

Keywords:

TIM-3-IN-2