2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. 2554620-04-9

2554620-04-9

HIV-1 inhibitor-21 Chemical Structure

2554620-04-9

Chemical Structure

  • HIV-1 inhibitor-21
  • CAS No: 2554620-04-9
    Formula: C28H24N6O2
    Molecular Weight: 476.53
  • IUPAC Name: (E)-4-((4-((4-(2-cyanovinyl)-2,6-dimethylphenyl)amino)-6,7-dimethoxyquinazolin-2-yl)amino)benzonitrile
  • InChIKey: JZWWKCUXZXWRSL-AATRIKPKSA-N
  • SMILES: N#CC1=CC=C(NC2=NC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=C4C=C(OC)C(OC)=CC4=N2)C=C1

Biological Activity: HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM)[1].

Cat. No. Product Name Purity Description
HY-146015 HIV-1 inhibitor-21 HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM).

References

[1]. Han S, et al. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2020;185:111874. [Content Brief]

Keywords:

HIV-1 inhibitor-21