2. MAPK/ERK Pathway
  3. p38 MAPK JNK
  4. 2166616-75-5

2166616-75-5

LY-3381916 Chemical Structure

2166616-75-5

Chemical Structure

  • LY-3381916
  • Synonym(s): IDO1-IN-5
  • CAS No: 2166616-75-5
    Formula: C23H25FN2O3
    Molecular Weight: 396.45
  • IUPAC Name: (R)-4-fluoro-N-(1-(1-(tetrahydro-2H-pyran-4-carbonyl)indolin-5-yl)ethyl)benzamide
  • InChIKey: NUBWFWVVKLRSHS-OAHLLOKOSA-N
  • SMILES: FC1=CC=C(C(N[C@H](C)C2=CC=C(N(C(C3CCOCC3)=O)CC4)C4=C2)=O)C=C1

Biological Activity: LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[1].

Cat. No. Product Name Purity Description
HY-111540 LY-3381916 99.92% LY-3381916 (IDO1-IN-5) is a potent, selective and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

References

[1]. Frank C. Dorsey, et al. Abstract 5245: Identification and characterization of the IDO1 inhibitor LY3381916. Cancer Research. 2018, 78(13).

Keywords:

LY-3381916