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  6. 1245606-71-6

1245606-71-6

TPE-MI Chemical Structure

1245606-71-6

Chemical Structure

  • TPE-MI
  • Synonym(s): Tetraphenylethene maleimide
  • CAS No: 1245606-71-6
    Formula: C31H23NO2
    Molecular Weight: 441.52
  • IUPAC Name: (Z)-1-(4-(1,2-diphenyl-2-(p-tolyl)vinyl)phenyl)-1H-pyrrole-2,5-dione
  • InChIKey: CIMVFJJQFXGASK-KTMFPKCZSA-N
  • SMILES: O=C(C=C1)N(C2=CC=C(/C(C3=CC=CC=C3)=C(C4=CC=C(C)C=C4)/C5=CC=CC=C5)C=C2)C1=O

Biological Activity: TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells. TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum [1][2].

Cat. No. Product Name Purity Description
HY-143218 TPE-MI 98.71% TPE-MI (Tetraphenylethene maleimide) is a thiol probe for measuring unfolded protein load and proteostasis in cells. TPE-MI can report imbalances in proteostasis in induced pluripotent stem cell models of Huntington disease, as well as cells transfected with mutant Huntington exon 1 before the formation of visible aggregates. TPE-MI also detects protein damage following dihydroartemisinin research of the malaria parasitesPlasmodium falciparum .

References

[1]. Chen MZ, et al. A thiol probe for measuring unfolded protein load and proteostasis in cells. Nat Commun. 2017;8(1):474. Published 2017 Sep 7. [Content Brief]
[2]. Hu Q, et al. In Situ Monitored Vortex Fluidic-Mediated Protein Refolding/Unfolding Using an Aggregation-Induced Emission Bioprobe. Molecules. 2021;26(14):4273. Published 2021 Jul 14. [Content Brief]

Keywords:

TPE-MI