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3063166-64-0

Tau ligand-1 Chemical Structure

3063166-64-0

Chemical Structure

  • Tau ligand-1
  • CAS No: 3063166-64-0
    Formula: C17H16FN3O
    Molecular Weight: 297.33
  • InChIKey: VMFGXNQGZROBNK-UHFFFAOYSA-N
  • SMILES: FC1=NC(N2CCOCC2)=CC=C1C3=CC4=C(N3)C=CC=C4

Biological Activity: Tau ligand-1 (Compound 75) is a ligand for aggregated tau protein that can penetrate the blood-brain barrier[1]. In tissues from patients with Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 exhibits high affinity for aggregated tau protein, with equilibrium dissociation constant (KD) values ranging from 1 to 3.8 nM[1]. Tau ligand-1 can serve as a potential positron emission tomography (PET) tracer and holds promise for application in positron emission tomography imaging studies of tau-related diseases in the central nervous system[1].

Cat. No. Product Name Purity Description
HY-139745 FPI-1523 sodium 99.79% FPI-1523 sodium, a derivative of Avibactam, is a potent β-lactamase inhibitor, with Kds of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. FPI-1523 sodium also inhibits PBP2, with an IC50 of 3.2 μM. FPI-1523 sodium exhibits considerable antimicrobial activity.

References

[1]. Stehouwer JS, et al. Structure-Activity Relationships and Evaluation of 2-(Heteroaryl-cycloalkyl)-1H-indoles as Tauopathy Positron Emission Tomography Radiotracers. J Med Chem. 2025 Mar 27;68(6):6462-6492. [Content Brief]

Keywords:

Tau ligand-1