2. GPCR/G Protein
  3. Neuromedin U Receptor (NMUR)
  4. 1185189-97-2

1185189-97-2

R-PSOP Chemical Structure

1185189-97-2

Chemical Structure

  • R-PSOP
  • CAS No: 1185189-97-2
    Formula: C20H22N4O2
    Molecular Weight: 350.41
  • IUPAC Name: (R)-1-phenyl-3-(3'H-4-azaspiro[bicyclo[2.2.2]octane-2,2'-furo[2,3-b]pyridin]-5'-yl)urea
  • InChIKey: BUOWEYLLAFLKCW-FQEVSTJZSA-N
  • SMILES: O=C(NC1=CC=CC=C1)NC2=CN=C3O[C@]4(CC3=C2)C(CC5)CCN5C4

Biological Activity: R-PSOP is highly potent and selective nonpeptidic NMUR2 antagonist. R-PSOP binds to NMUR2 with the Kis of 52 and 32 nM for the human and rat NMUR2, respectively. R-PSOP shows moderate CNS penetration. R-PSOP can be used for the research of the eating disorders, obesity, pain, and stress-related disorders[1].

Cat. No. Product Name Purity Description
HY-145086 R-PSOP 99.90% R-PSOP is highly potent and selective nonpeptidic NMUR2 antagonist. R-PSOP binds to NMUR2 with the Kis of 52 and 32 nM for the human and rat NMUR2, respectively. R-PSOP shows moderate CNS penetration. R-PSOP can be used for the research of the eating disorders, obesity, pain, and stress-related disorders.

References

[1]. Liu JJ, et al. Discovery and pharmacological characterization of a small-molecule antagonist at neuromedin U receptor NMUR2. J Pharmacol Exp Ther. 2009;330(1):268-275. [Content Brief]

Keywords:

R-PSOP