2. Epigenetics PI3K/Akt/mTOR
  3. AMPK
  4. 2632259-93-7

2632259-93-7

ZW4864 Chemical Structure

2632259-93-7

Chemical Structure

  • ZW4864
  • CAS No: 2632259-93-7
    Formula: C33H43ClN6O3
    Molecular Weight: 607.19
  • IUPAC Name: (R)-4-(2-(3-(3-((4-(1H-pyrazol-4-yl)benzyl)(cyclopropyl)carbamoyl)piperidin-1-yl)phenoxy)-2-methylpropanoyl)piperazin-1-ium chloride
  • InChIKey: PQRRIGABHUYXRQ-UFTMZEDQSA-N
  • SMILES: O=C(N(CC1=CC=C(C=C1)C2=CNN=C2)C3CC3)[C@H]4CN(CCC4)C5=CC=CC(OC(C)(C(N6CC[NH2+]CC6)=O)C)=C5.[Cl-]

Biological Activity: ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM[1].

Cat. No. Product Name Purity Description
HY-132300 ZW4864 97.09% ZW4864 is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction (β catenin/BCL9 PPI) inhibitor. ZW4864 inhibits β catenin/BCL9 PPI with a Ki value of 0.76 μM and an IC50 value of 0.87 μM.

References

[1]. Wang Z, et al. Discovery of an Orally Bioavailable Small-Molecule Inhibitor for the β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction. J Med Chem. 2021;64(16):12109-12131. [Content Brief]

Keywords:

ZW4864