2. Others Anti-infection
  3. Isotope-Labeled Compounds Fungal Bacterial Antibiotic
  4. 2755644-33-6

2755644-33-6

Epalrestat-d<sub>5</sub> Chemical Structure

2755644-33-6

Chemical Structure

  • Epalrestat-d5
  • Synonym(s): ONO2235-d5
  • CAS No: 2755644-33-6
    Formula: C15H8D5NO3S2
    Molecular Weight: 324.43
  • IUPAC Name: 2-((Z)-5-((E)-2-methyl-3-(phenyl-d5)allylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid
  • InChIKey: CHNUOJQWGUIOLD-CUEOMABLSA-N
  • SMILES: O=C(N1CC(O)=O)/C(SC1=S)=C/C(C)=C/C2=C(C([2H])=C(C([2H])=C2[2H])[2H])[2H]

Biological Activity: Epalrestat-d5 is deuterium labeled Epalrestat. Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy[1][2][3][4].

Cat. No. Product Name Purity Description
HY-W653944 Epalrestat-d5 Epalrestat-d5 is deuterium labeled Epalrestat. Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy.
HY-66009R Epalrestat (Standard) ≥98% Epalrestat (Standard) is the analytical standard of Epalrestat. This product is intended for research and analytical applications. Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy.
HY-66009 Epalrestat 99.36% Epalrestat is an orally active aldose reductase inhibitor that acts on diabetic neuropathy.

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Ramirez, M.A. and N.L. Borja, Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy. Pharmacotherapy, 2008. 28(5): p. 646-55. [Content Brief]
[3]. He J, et al. The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation. Acta Pharmacol Sin. 2019 Jan;40(1):86-97. [Content Brief]
[4]. Okamoto, H., et al., Effects of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy and gastroparesis. Intern Med, 2003. 42(8): p. 655-64. [Content Brief]

Keywords:

Epalrestat-d5Epalrestat (Standard)Epalrestat