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1950628-94-0

TGFβRI-IN-1 Chemical Structure

1950628-94-0

Chemical Structure

  • TGFβRI-IN-1
  • CAS No: 1950628-94-0
    Formula: C20H14D3N5O2
    Molecular Weight: 362.40
  • IUPAC Name: N-(4-(3-(5-(methoxy-d3)pyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl)pyridin-2-yl)acetamide
  • InChIKey: VRPRBQAJAQCSCW-BMSJAHLVSA-N
  • SMILES: CC(NC1=NC=CC(C(N2)=C(C3=NC=C(OC([2H])([2H])[2H])C=C3)C4=C2C=CC=N4)=C1)=O

Biological Activity: TGFβRI-IN-1 is an oral active and selective TGFβ receptor type I (TGFβRI) kinase inhibitor, with IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively[1] .

Cat. No. Product Name Purity Description
HY-114192 TGFβRI-IN-1 TGFβRI-IN-1 is an oral active and selective TGFβ receptor type I (TGFβRI) kinase inhibitor, with IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively .

References

[1]. Yong Zhang, et al. Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents. ACS Med. Chem. Lett.20189111117-1122.

Keywords:

TGFβRI-IN-1