2. Others Anti-infection
  3. Fungal Isotope-Labeled Compounds
  4. 1217851-84-7

1217851-84-7

Voriconazole N-oxide-d<sub>3</sub> Chemical Structure

1217851-84-7

Chemical Structure

  • Voriconazole N-oxide-d3
  • Synonym(s): Voriconazole oxynitride-d3
  • CAS No: 1217851-84-7
    Formula: C16H11D3F3N5O2
    Molecular Weight: 368.33
  • IUPAC Name: 4-((2S,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl-1,1,1-d3)-5-fluoropyrimidine 1-oxide
  • InChIKey: KPLFPLUCFPRUHU-QLWAGJNOSA-N
  • SMILES: O[C@@](CN1N=CN=C1)(C2=CC=C(F)C=C2F)[C@@H](C([2H])([2H])[2H])C3=C(F)C=[N+]([O-])C=N3

Biological Activity: Voriconazole N-oxide-d3 (Voriconazole oxynitride-d3) is deuterium labeled Voriconazole N-oxide. Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB)[1][2].

Cat. No. Product Name Purity Description
HY-137989S Voriconazole N-oxide-d3 Voriconazole N-oxide-d3 (Voriconazole oxynitride-d3) is deuterium labeled Voriconazole N-oxide. Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB).
HY-137989 Voriconazole N-oxide Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB).

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Ona K, et, al. Voriconazole N-oxide and its ultraviolet B photoproduct sensitize keratinocytes to ultraviolet A. Br J Dermatol. 2015 Sep;173(3):751-9. [Content Brief]

Keywords:

Voriconazole N-oxide-d3Voriconazole N-oxide