2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Cell Cycle/DNA Damage Cytoskeleton
  3. Guanylate Cyclase Monoamine Oxidase NO Synthase Microtubule/Tubulin
  4. 615281-26-0

615281-26-0

NPD8790 Chemical Structure

615281-26-0

Chemical Structure

  • NPD8790
  • CAS No: 615281-26-0
    Formula: C20H24N2
    Molecular Weight: 292.42
  • InChIKey: GYCKWHDXPVMFDG-UHFFFAOYSA-N
  • SMILES: CC(CC1=CC=C(C=C1)C(C2=NC3=C(N2C)C=CC=C3)C)C

Biological Activity: NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC50 of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths[1].

Cat. No. Product Name Purity Description
HY-158423 NPD8790 NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC50 of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths.

References

[1]. Taylor Davie, et al. Identification of a family of species-selective complex I inhibitors as potential anthelmintics. Nat Commun. 2024 May 8;15(1):3367. [Content Brief]

Keywords:

NPD8790