2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. 1235397-05-3

1235397-05-3

PF-04856264 Chemical Structure

1235397-05-3

Chemical Structure

  • PF-04856264
  • CAS No: 1235397-05-3
    Formula: C20H15N5O3S2
    Molecular Weight: 437.49
  • IUPAC Name: 3-cyano-4-(2-(1-methyl-1H-pyrazol-5-yl)phenoxy)-N-(thiazol-2-yl)benzenesulfonamide
  • InChIKey: MKSKJVIBSRUWSZ-UHFFFAOYSA-N
  • SMILES: O=S(C1=CC=C(OC2=CC=CC=C2C3=CC=NN3C)C(C#N)=C1)(NC4=NC=CS4)=O

Biological Activity: PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect[1][2].

Cat. No. Product Name Purity Description
HY-12811 PF-04856264 98.10% PF-04856264 is a potent and selective Nav1.7 inhibitor, with IC50s of 28, 131, 19, and 42 nM for human, mouse, cynomolgus monkey and dog Nav1.7, respectively. PF-04856264 has low potency against the rat Nav1.7 channel. PF-04856264 shows analgesic effect.

References

[1]. McCormack K, et al. Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc Natl Acad Sci U S A. 2013;110(29):E2724-E2732. [Content Brief]
[2]. Deuis JR, et al. Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins (Basel). 2016;8(3):78. Published 2016 Mar 17. [Content Brief]

Keywords:

PF-04856264