1. Cell Cycle/DNA Damage Stem Cell/Wnt
  2. Casein Kinase Wnt
  3. 2762519-08-2

2762519-08-2

endo-BCN-PEG4-Val-Cit-PAB-MMAE Chemical Structure

2762519-08-2

Chemical Structure

  • endo-BCN-PEG4-Val-Cit-PAB-MMAE
  • CAS No: 2762519-08-2
    Formula: C80H127N11O19
    Molecular Weight: 1546.93
  • IUPAC Name: 4-((21S,24S)-1-((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)-21-isopropyl-3,19,22-trioxo-24-(3-ureidopropyl)-2,7,10,13,16-pentaoxa-4,20,23-triazapentacosan-25-amido)benzyl ((S)-1-(((S)-1-(((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)
  • InChIKey: SQKNRIOHJGDSGO-SRLCYROHSA-N
  • SMILES: CC[C@@H]([C@H](N(C([C@@H](NC([C@@H](N(C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(CCOCCOCCOCCOCCNC(OC[C@@H]2[C@@]3([H])[C@]2([H])CCC#CCC3)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C1)=O)C)C(C)C)=O)C(C)C)=O)C)[C@H](OC)CC(N4CCC[C@H]4[C@H](OC)[C@H](C(N[C@@H]([C@@H](O)C5=CC=CC=C5)C)=O)C)=O)C

Biological Activity: endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. endo-BCN-PEG4-Val-Cit-PAB-MMAE is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

References