2. PI3K/Akt/mTOR Metabolic Enzyme/Protease Membrane Transporter/Ion Channel
  3. Akt GLUT Phosphatase
  4. 2416338-55-9

2416338-55-9

Microtubule inhibitor 5 Chemical Structure

2416338-55-9

Chemical Structure

  • Microtubule inhibitor 5
  • CAS No: 2416338-55-9
    Formula: C22H15FN2O4
    Molecular Weight: 390.36
  • IUPAC Name: (Z)-3-((Z)-3-(4-fluorophenoxy)benzylidene)-6-(furan-2-ylmethylene)piperazine-2,5-dione
  • InChIKey: HVDIOKFBMGISBM-YXZJEIOKSA-N
  • SMILES: O=C1N/C(C(N/C1=C\C2=CC(OC3=CC=C(C=C3)F)=CC=C2)=O)=C\C4=CC=CO4

Biological Activity: Microtubule inhibitor 5 (compound 17f) is a potent microtubule inhibitor. Microtubule inhibitor 5 shows cytotoxicity with an IC50 value of 154.5 nM for NCI-H460 cells. Microtubule inhibitor 5 shows good cell permeability[1].

Cat. No. Product Name Purity Description
HY-147726 Microtubule inhibitor 5 Microtubule inhibitor 5 (compound 17f) is a potent microtubule inhibitor. Microtubule inhibitor 5 shows cytotoxicity with an IC50 value of 154.5 nM for NCI-H460 cells. Microtubule inhibitor 5 shows good cell permeability.

References

[1]. Ding Z, et al. Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer. Bioorg Med Chem. 2020 May 15;28(10):115435. [Content Brief]

Keywords:

Microtubule inhibitor 5