2. GPCR/G Protein
  3. Adenosine Receptor
  4. 2413565-19-0

2413565-19-0

COX-2-IN-26 Chemical Structure

2413565-19-0

Chemical Structure

  • COX-2-IN-26
  • CAS No: 2413565-19-0
    Formula: C23H21N7OS3
    Molecular Weight: 507.65
  • IUPAC Name: (E)-2-(((E)-1-((4-(2-(methylthio)-1H-benzo[d]imidazol-1-yl)thiazol-2-yl)amino)propan-2-ylidene)hydrazono)-3-phenylthiazolidin-4-one
  • InChIKey: LARVQAAGTBVQRP-BOJCHKAJSA-N
  • SMILES: O=C1N(C2=CC=CC=C2)/C(SC1)=N\N=C(CNC3=NC(N4C(SC)=NC5=C4C=CC=C5)=CS3)/C

Biological Activity: COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile[1].

Cat. No. Product Name Purity Description
HY-150550 COX-2-IN-26 COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 µM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile.

References

[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403. [Content Brief]

Keywords:

COX-2-IN-26