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2242616-04-0

Raphin1 acetate Chemical Structure

2242616-04-0

Chemical Structure

  • Raphin1 acetate
  • CAS No: 2242616-04-0
    Formula: C10H12Cl2N4O2
    Molecular Weight: 291.13
  • IUPAC Name: (E)-2-(2,3-dichlorobenzylidene)hydrazine-1-carboximidamide acetate
  • InChIKey: WSDLUFBVKWLRSN-GAYQJXMFSA-N
  • SMILES: N=C(N/N=C/C1=CC=CC(Cl)=C1Cl)N.CC(O)=O

Biological Activity: Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease[1].

Cat. No. Product Name Purity Description
HY-123960A Raphin1 acetate 99.93% Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). Raphin1 acetate binds strongly to the R15B-PP1c holophosphatase (Kd=33 nM), and shows ~30-fold selective in binding R15B-PP1c over R15A-PP1c. Raphin1 acetate crosses the blood-brain barrier, and reduces organismal and molecular deficits in a mouse model of a protein misfolding disease.

References

[1]. Krzyzosiak A, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018 Aug 23;174(5):1216-1228.e19. [Content Brief]

Keywords:

Raphin1 acetate