2. Anti-infection Apoptosis
  3. Bacterial Parasite Apoptosis Antibiotic
  4. 2922824-07-3

2922824-07-3

GPX4-IN-6 Chemical Structure

2922824-07-3

Chemical Structure

  • GPX4-IN-6
  • CAS No: 2922824-07-3
    Formula: C18H17BrFNO5
    Molecular Weight: 426.23
  • InChIKey: RKMUVAANQXYLLV-UHFFFAOYSA-N
  • SMILES: O=C(CBr)N(C1=CC(OC)=C(F)C(OC)=C1)C2=CC(OCCO3)=C3C=C2

Biological Activity: GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) [1].

Cat. No. Product Name Purity Description
HY-155664 GPX4-IN-6 GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) .

References

[1]. Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059. [Content Brief]

Keywords:

GPX4-IN-6