2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. 1352226-87-9

1352226-87-9

(S)-Ceralasertib Chemical Structure

1352226-87-9

Chemical Structure

  • (S)-Ceralasertib
  • Synonym(s): (S)-AZD6738
  • CAS No: 1352226-87-9
    Formula: C20H24N6O2S
    Molecular Weight: 412.51
  • IUPAC Name: (S)-imino(methyl)(1-(6-((R)-3-methylmorpholino)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)cyclopropyl)-l6-sulfanone
  • InChIKey: OHUHVTCQTUDPIJ-MUWSIPGASA-N
  • SMILES: O=[S@](C1(CC1)C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(N5CCOC[C@H]5C)=C2)(C)=N

Biological Activity: (S)-Ceralasertib ((S)-AZD6738) is extracted from patent WO2011154737A1, Compound II, exhibits an IC50 of 2.578 nM[1]. (S)-Ceralasertib is a potent and selective sulfoximine morpholinopyrimidine ATR inhibitor with excellent preclinical physicochemical and pharmacokinetic (PK) characteristics. (S)-Ceralasertib is developed improving aqueous solubility and eliminates CYP3A4 time-dependent inhibition[2].

References

[1]. By Foote, et al. Morpholinopyrimidines as ATR kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer. PCT Int. Appl. (2011), WO 2011154737 A1 20111215.
[2]. Foote KM, et al. Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutatedand Rad3 Related (ATR) Kinase with Application as an Anticancer Agent. J Med Chem. 2018 Nov 21;61(22):9889-9907. [Content Brief]

Keywords:

(S)-Ceralasertib