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  6. 1911579-04-8

1911579-04-8

GS-704277 Chemical Structure

1911579-04-8

Chemical Structure

  • GS-704277
  • CAS No: 1911579-04-8
    Formula: C15H19N6O8P
    Molecular Weight: 442.32
  • IUPAC Name: ((((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)-L-alanine
  • InChIKey: IYHPTSNEWCZBDF-NIFWRESRSA-N
  • SMILES: OC([C@H](C)NP(OC[C@@H]1[C@@H](O)[C@@H](O)[C@@](C2=CC=C3N2N=CN=C3N)(C#N)O1)(O)=O)=O

Biological Activity: GS-704277 is an alanine metabolite of Remdesivir (HY-104077). GS-704277 is further hydrolyzed to GA-441524 (HY-103586) with antiviral activity. Remdesivir, a nucleoside analogue with effective antiviral activity, is highly effective in the control of SARS-CoV-2 (COVID-19) infection[1][2][3][4][5].

Cat. No. Product Name Purity Description
HY-136303 GS-704277 99.63% GS-704277 is an alanine metabolite of Remdesivir (HY-104077). GS-704277 is further hydrolyzed to GA-441524 (HY-103586) with antiviral activity. Remdesivir, a nucleoside analogue with effective antiviral activity, is highly effective in the control of SARS-CoV-2 (COVID-19) infection.

References

[1]. Eastman RT, et al. Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 [published correction appears in ACS Cent Sci. 2020 Jun 24;6(6):1009]. ACS Cent Sci. 2020;6(5):672-683. [Content Brief]
[2]. Wang M, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271. [Content Brief]
[3]. Yan VC, et al. Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity. Antimicrob Agents Chemother. 2020 Nov 17;64(12):e01920-20. [Content Brief]
[4]. Sullivan JT. Postmarketing pharmacovigilance: Remdesivir and cardiovascular events. Clin Transl Sci. 2022 Apr;15(4):813-815. [Content Brief]
[5]. Prabha PK, et al. Can changing the prodrug moiety in remdesivir be a life-saving strategy in COVID-19 infection? Indian J Med Res. 2023 Jan;157(1):100-103. [Content Brief]

Keywords:

GS-704277