2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. 130905-04-3

130905-04-3

Phendioxan Chemical Structure

130905-04-3

Chemical Structure

  • Phendioxan
  • CAS No: 130905-04-3
    Formula: C25H27NO5
    Molecular Weight: 421.49
  • IUPAC Name: 2-(2,6-dimethoxyphenoxy)-N-(((2S,3S)-3-phenyl-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)ethan-1-amine
  • InChIKey: UVEKKXRFQCNLQE-ZEQRLZLVSA-N
  • SMILES: COC(C=CC=C1OC)=C1OCCNC[C@H]2[C@H](C3=CC=CC=C3)OC4=CC=CC=C4O2

Biological Activity: Phendioxan is a compound with binding activity at the α(1)-adrenaline receptor subtype. The facilitated membrane diffusion of phendioxan is thought to be associated with improved α(1d)-AR affinity. Docking simulations of phendioxan at biological targets supported the stoichiometric analysis and revealed the importance of polar, electrostatic, hydrophobic, and shape effects of its phenoxy terminal orthogonal substituents on ligand binding[1].

Cat. No. Product Name Purity Description
HY-118260 Phendioxan Phendioxan is a compound with binding activity at the α(1)-adrenaline receptor subtype. The facilitated membrane diffusion of phendioxan is thought to be associated with improved α(1d)-AR affinity. Docking simulations of phendioxan at biological targets supported the stoichiometric analysis and revealed the importance of polar, electrostatic, hydrophobic, and shape effects of its phenoxy terminal orthogonal substituents on ligand binding.

References

[1]. Structure-activity relationships in 1,4-benzodioxan-related compounds. 10. Novel α1-adrenoreceptor antagonists related to openphendioxan: synthesis, biological evaluation, and α1d computational study

Keywords:

Phendioxan