2. Anti-infection
  3. Reverse Transcriptase HIV
  4. 1312345-89-3

1312345-89-3

GSK5750 Chemical Structure

1312345-89-3

Chemical Structure

  • GSK5750
  • CAS No: 1312345-89-3
    Formula: C16H12N4O2S
    Molecular Weight: 324.36
  • IUPAC Name: 4-((benzo[b]thiophen-2-ylmethyl)amino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one
  • InChIKey: JMKYKCCBXRBHQY-UHFFFAOYSA-N
  • SMILES: O=C1N(O)C2=NC=CC=C2C(NCC3=CC4=CC=CC=C4S3)=N1

Biological Activity: GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC50 value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism[1].

Cat. No. Product Name Purity Description
HY-116454 GSK5750 GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC50 value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism.

References

[1]. Beilhartz GL, et al. Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation. J Biol Chem. 2014 Jun 6;289(23):16270-7. [Content Brief]

Keywords:

GSK5750