1. Metabolic Enzyme/Protease
  2. Cytochrome P450
  3. 93076-89-2

93076-89-2

R 59-022 Chemical Structure

93076-89-2

Chemical Structure

  • R 59-022
  • Synonym(s): DKGI-I; Diacylglycerol kinase inhibitor I
  • CAS No: 93076-89-2
    Formula: C27H26FN3OS
    Molecular Weight: 459.58
  • IUPAC Name: 6-(2-(4-((4-fluorophenyl)(phenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
  • InChIKey: MFVJXLPANKSLLD-UHFFFAOYSA-N
  • SMILES: O=C1C(CCN(CC/2)CCC2=C(C3=CC=CC=C3)/C4=CC=C(F)C=C4)=C(C)N=C5N1C=CS5

Biological Activity: R 59-022 (DKGI-I) is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils[1][2][3][4].

Cat. No. Product Name Purity Description
HY-107613 R 59-022 99.82% R 59-022 (DKGI-I) is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.

References

Keywords:

R 59-022