2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Cytochrome P450
  4. 1340593-70-5

1340593-70-5

Quilseconazole Chemical Structure

1340593-70-5

Chemical Structure

  • Quilseconazole
  • Synonym(s): VT-1129
  • CAS No: 1340593-70-5
    Formula: C22H14F7N5O2
    Molecular Weight: 513.37
  • IUPAC Name: (R)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl)-1-(5-(4-(trifluoromethoxy)phenyl)pyridin-2-yl)propan-2-ol
  • InChIKey: NCEHACHJIXJSPD-FQEVSTJZSA-N
  • SMILES: O[C@@](CN1C=NN=N1)(C(C=CC(F)=C2)=C2F)C(F)(C3=CC=C(C4=CC=C(OC(F)(F)F)C=C4)C=N3)F

Biological Activity: Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes[1].

Cat. No. Product Name Purity Description
HY-109040 Quilseconazole 98.98% Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes.

References

[1]. Lockhart SR, et al. The Investigational Fungal Cyp51 Inhibitor VT-1129 Demonstrates Potent In Vitro Activity against Cryptococcus neoformans and Cryptococcus gattii. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2528-31. [Content Brief]

Keywords:

Quilseconazole