2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. 2568507-14-0

2568507-14-0

PROTAC SMARCA2/4-degrader-8 Chemical Structure

2568507-14-0

Chemical Structure

  • PROTAC SMARCA2/4-degrader-8
  • CAS No: 2568507-14-0
    Formula: C50H61N11O5S
    Molecular Weight: 928.16
  • InChIKey: FJLMAFZCCWWNOZ-BOXUEZMPSA-N
  • SMILES: NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C(C6CCC(CC6)CC(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O)C=N5)C(CC4)C3

Biological Activity: PROTAC SMARCA2/4-degrader-8 (Compound I-502) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2. PROTAC SMARCA2/4-degrader-8 degrades SMARCA2 with DC50 <100 nM in A549 and in MV411, degrades SMARCA4 with DC50<100 nM in MV411(Pink: Ligand for target protein (HY-159545); Black: Linker (HY-W063924); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))[1]

Cat. No. Product Name Purity Description
HY-N1357 Rauvotetraphylline E Rauvotetraphylline E is a Alkaloids product that can be isolated from the aerial parts of Rauvolfia tetraphylla..

References

[1]. Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.

Keywords:

PROTAC SMARCA2/4-degrader-8