2. Cell Cycle/DNA Damage Stem Cell/Wnt MAPK/ERK Pathway
  3. Casein Kinase ERK CDK
  4. 1353867-91-0

1353867-91-0

Longdaysin Chemical Structure

1353867-91-0

Chemical Structure

  • Longdaysin
  • CAS No: 1353867-91-0
    Formula: C16H16F3N5
    Molecular Weight: 335.33
  • IUPAC Name: 9-isopropyl-N-(3-(trifluoromethyl)benzyl)-9H-purin-6-amine
  • InChIKey: REKSFCCYDQMSIN-UHFFFAOYSA-N
  • SMILES: FC(F)(F)C1=CC=CC(CNC2=NC=NC3=C2N=CN3C(C)C)=C1

Biological Activity: Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC50s of  5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively[1][2].

Cat. No. Product Name Purity Description
HY-18285 Longdaysin 99.83% Longdaysin is a inhibitor of the Wnt/β-catenin signaling pathway, which exerts antitumor effect through blocking CK1δ/ε-dependent Wnt signaling. Longdaysin inhibits CK1α, CK1δ, CDK7, and ERK2 with IC50s of  5.6 µM, 8.8 µM, 29 µM, and 52 µM, respectively.

References

[1]. Griffett K, et al. The mammalian clock and chronopharmacology. Bioorganic & Medicinal Chemistry Letters, 2013, 23(7):1929-1934..
[2]. Hirota T, et al. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. PLoS Biol. 2010 Dec 14;8(12):e1000559. [Content Brief]

Keywords:

Longdaysin