2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. 1354030-52-6

1354030-52-6

UNC9995 Chemical Structure

1354030-52-6

Chemical Structure

  • UNC9995
  • CAS No: 1354030-52-6
    Formula: C20H21Cl2N3OS
    Molecular Weight: 422.37
  • IUPAC Name: 5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)benzo[d]thiazole
  • InChIKey: VBHBKXBUHHJVBZ-UHFFFAOYSA-N
  • SMILES: ClC1=CC=CC(N2CCN(CC2)CCCOC3=CC4=C(C=C3)SC=N4)=C1Cl

Biological Activity: UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions[1].

Cat. No. Product Name Purity Description
HY-120920 UNC9995 99.38% UNC9995 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions.

References

[1]. Liu Y, et al. β-Arrestin2-biased Drd2 agonist UNC9995 alleviates astrocyte inflammatory injury via interaction between β-arrestin2 and STAT3 in mouse model of depression. J Neuroinflammation. 2022 Oct 1;19(1):240. [Content Brief]

Keywords:

UNC9995