2. Others Metabolic Enzyme/Protease
  3. Isotope-Labeled Compounds Angiotensin-converting Enzyme (ACE)
  4. 1426828-06-9

1426828-06-9

Azide-PEG3-Desthiobiotin Chemical Structure

1426828-06-9

Chemical Structure

  • Azide-PEG3-Desthiobiotin
  • CAS No: 1426828-06-9
    Formula: C18H34N6O5
    Molecular Weight: 414.50
  • IUPAC Name: N-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)-6-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)hexanamide
  • InChIKey: JIQVKRRASYKCEL-JKSUJKDBSA-N
  • SMILES: O=C(NCCOCCOCCOCCN=[N+]=[N-])CCCCC[C@H]([C@H](C)N1)NC1=O

Biological Activity: Azide-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Desthiobiotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No. Product Name Purity Description
HY-W096120 Azide-PEG3-Desthiobiotin ≥96.0% Azide-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG3-Desthiobiotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Keywords:

Azide-PEG3-Desthiobiotin