2. Neuronal Signaling
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  4. 2414373-55-8

2414373-55-8

CDK6/9-IN-1 Chemical Structure

2414373-55-8

Chemical Structure

  • CDK6/9-IN-1
  • CAS No: 2414373-55-8
    Formula: C22H25ClN8O
    Molecular Weight: 452.94
  • IUPAC Name: N-(3-((5-chloro-2-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)pyrimidin-4-yl)amino)phenyl)acetamide
  • InChIKey: GVJLKAACQAJVQS-UHFFFAOYSA-N
  • SMILES: CC(NC1=CC=CC(NC2=NC(NC3=NC=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)=C1)=O

Biological Activity: CDK6/9-IN-1 (compound 66) is an orally active active and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively[1].

Cat. No. Product Name Purity Description
HY-131063 CDK6/9-IN-1 CDK6/9-IN-1 (compound 66) is an orally active active and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively.

References

[1]. Yang Wang, et al. Discovery and SARs of 5-Chloro- N4-phenyl- N2-(pyridin-2-yl)pyrimidine-2,4-diamine Derivatives as Oral Available and Dual CDK 6 and 9 Inhibitors With Potent Antitumor Activity. J Med Chem. 2020 Mar 26;63(6):3327-3347. [Content Brief]

Keywords:

CDK6/9-IN-1