2. Neuronal Signaling
  3. Legumain
  4. 1638148-50-1

1638148-50-1

DI-82 Chemical Structure

1638148-50-1

Chemical Structure

  • DI-82
  • CAS No: 1638148-50-1
    Formula: C20H26N6O4S3
    Molecular Weight: 510.65
  • IUPAC Name: (R)-N-(2-(5-(4-(1-((4,6-diaminopyrimidin-2-yl)thio)ethyl)-5-methylthiazol-2-yl)-2-methoxyphenoxy)ethyl)methanesulfonamide
  • InChIKey: MBPWFMBRNJJXFY-GFCCVEGCSA-N
  • SMILES: NC1=NC(S[C@H](C)C(N=C2C(C=C3OCCNS(=O)(C)=O)=CC=C3OC)=C(S2)C)=NC(N)=C1

Biological Activity: DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity[1].

Cat. No. Product Name Purity Description
HY-136499 DI-82 ≥98.0% DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity.

References

[1]. Julian Nomme, et al. Structure-guided Development of Deoxycytidine Kinase Inhibitors With Nanomolar Affinity and Improved Metabolic Stability. J Med Chem. 2014 Nov 26;57(22):9480-94. [Content Brief]

Keywords:

DI-82