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1400888-63-2

(2R,3R)-E1R Chemical Structure

1400888-63-2

Chemical Structure

  • (2R,3R)-E1R
  • CAS No: 1400888-63-2
    Formula: C13H16N2O2
    Molecular Weight: 232.28
  • IUPAC Name: 2-((2R,3R)-2-methyl-5-oxo-3-phenylpyrrolidin-1-yl)acetamide
  • InChIKey: ZTGRWYMPQCQTHD-KOLCDFICSA-N
  • SMILES: O=C(N)CN1[C@H](C)[C@@H](C2=CC=CC=C2)CC1=O

Biological Activity: (2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].

Cat. No. Product Name Purity Description
HY-116463C (2R,3R)-E1R 98.79% (2R,3R)-E1R (Compound 2b) is an enantiomer of E1R. (2R,3R)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders.

References

[1]. Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71. [Content Brief]

Keywords:

(2R,3R)-E1R