2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. 1567836-15-0

1567836-15-0

CPUY192018 Chemical Structure

1567836-15-0

Chemical Structure

  • CPUY192018
  • CAS No: 1567836-15-0
    Formula: C28H26N2O10S2
    Molecular Weight: 614.64
  • IUPAC Name: 2,2'-(naphthalene-1,4-diylbis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid
  • InChIKey: KWSIQJUNYMMCTB-UHFFFAOYSA-N
  • SMILES: O=C(O)CN(C1=C2C=CC=CC2=C(N(S(=O)(C3=CC=C(OC)C=C3)=O)CC(O)=O)C=C1)S(=O)(C4=CC=C(OC)C=C4)=O

Biological Activity: CPUY192018 is a potent Keap1-Nrf2-ARE inhibitor with an IC50 of 0.63 µM. CPUY192018 exhibits induction of Nrf2-dependent gene NQO1 at 100 µM[1].

Cat. No. Product Name Purity Description
HY-120371 CPUY192018 98.99% CPUY192018 is a potent Keap1-Nrf2-ARE inhibitor with an IC50 of 0.63 µM. CPUY192018 exhibits induction of Nrf2-dependent gene NQO1 at 100 µM.

References

[1]. Lee S, et al. Structure-activity relationships of 1,4-bis(arylsulfonamido)-benzene or naphthalene-N,N'-diacetic acids with varying C2-substituents as inhibitors of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2022; 237:114380. [Content Brief]

Keywords:

CPUY192018